Corneal neovascularization blood vessel growth caused by chronic hypoxia from contact lens wear at Hirocon Singapore

Corneal Neovascularization: A Comprehensive Review

Corneal neovascularization is the growth of new blood vessels into the cornea, which is normally avascular (lacking blood vessels). It can be a sight-threatening condition. This process can occur due to various factors, including:

  1. Hypoxia: Insufficient oxygen supply to the cornea, often seen in contact lens wearers.
  2. Infection: Certain infections can trigger an inflammatory response that promotes vascular growth.
  3. Inflammation: Conditions like keratitis or conjunctivitis can lead to neovascularization.
  4. Trauma: Injury to the cornea may stimulate new vessel growth as part of the healing process.
Corneal neovascularization blood vessel growth caused by chronic hypoxia from contact lens wear at Hirocon Singapore
Photo from: https://www.reviewofcontactlenses.com/article/when-the-problem-is-not-infectious

Symptoms

  • Visual disturbances or blurriness
  • Redness around the cornea
  • Discomfort or irritation
  • Increased sensitivity to light
  • Intolerance of contact lenses wear

Diagnosis

Diagnosis is typically made through a comprehensive eye exam (Slit-Lamp Examination)

  • Addressing the underlying cause: For example, improving oxygenation for contact lens wearers.
  • Medications: Corticosteroids or anti-VEGF agents may be used to reduce inflammation or inhibit vessel growth.
  • Surgery: In severe cases, surgical options such as limbal stem cell transplantation may be considered.

Prevention

  • Maintaining proper contact lens hygiene: switch to daily disaposable/Silicon Hydrogel material lenses and NO sleeping/naping with lenses on.
  • Avoiding eye irritants, and
  • Regular eye exams can help prevent corneal neovascularization. 

If you have more specific questions or need information on a particular aspect, feel free to ask!

Source: BSIP / UIG via Getty Images
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