Corneal Neovascularization: A Comprehensive Review

 

Corneal neovascularization is the growth of new blood vessels into the cornea, which is normally avascular (lacking blood vessels). It can be a sight-threatening condition. This process can occur due to various factors, including:

  1. Hypoxia: Insufficient oxygen supply to the cornea, often seen in contact lens wearers.
  2. Infection: Certain infections can trigger an inflammatory response that promotes vascular growth.
  3. Inflammation: Conditions like keratitis or conjunctivitis can lead to neovascularization.
  4. Trauma: Injury to the cornea may stimulate new vessel growth as part of the healing process.
When the Problem is Not Infectious
Photo from: https://www.reviewofcontactlenses.com/article/when-the-problem-is-not-infectious

Symptoms

  • Visual disturbances or blurriness
  • Redness around the cornea
  • Discomfort or irritation
  • Increased sensitivity to light
  • Intolerance of contact lenses wear

Diagnosis

Diagnosis is typically made through a comprehensive eye exam (Slit-Lamp Examination)

  • Addressing the underlying cause: For example, improving oxygenation for contact lens wearers.
  • Medications: Corticosteroids or anti-VEGF agents may be used to reduce inflammation or inhibit vessel growth.
  • Surgery: In severe cases, surgical options such as limbal stem cell transplantation may be considered.

Prevention

  • Maintaining proper contact lens hygiene: switch to daily disaposable/Silicon Hydrogel material lenses and NO sleeping/naping with lenses on.
  • Avoiding eye irritants, and
  • Regular eye exams can help prevent corneal neovascularization. 

If you have more specific questions or need information on a particular aspect, feel free to ask!

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